Ontology highlight
ABSTRACT:
SUBMITTER: Borkowski AW
PROVIDER: S-EPMC4289479 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
The Journal of investigative dermatology 20140812 2
UV damage to the skin leads to the release of noncoding RNA (ncRNA) from necrotic keratinocytes that activates Toll-like receptor 3 (TLR3). This release of ncRNA triggers inflammation in the skin following UV damage. Recently, TLR3 activation was also shown to aid wound repair and increase the expression of genes associated with permeability barrier repair. Here, we sought to test whether skin barrier repair after UVB damage is dependent on the activation of TLR3. We observed that multiple ncRNA ...[more]