Ontology highlight
ABSTRACT:
SUBMITTER: Belcher J
PROVIDER: S-EPMC2735475 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Belcher John J Sansone Samuel S Fernandez Nicholas F NF Haskins William E WE Brancaleon Lorenzo L
The journal of physical chemistry. B 20090401 17
We investigated the effects that the irradiation of a tetra-anionic porphyrin (mesotetrakis(sulfonatophenyl)porphyrin) noncovalently bound to beta-lactoglobulin (BLG) produces on the conformation of the protein. Although BLG is not a potential target for the biomedical applications of porphyrins, it is a useful model for investigating the effects of photoactive ligands on small globular proteins. We show in this paper that irradiation causes a large unfolding of the protein and that the conforma ...[more]