Ontology highlight
ABSTRACT:
SUBMITTER: Lau E
PROVIDER: S-EPMC2735493 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Lau Eric E Chiang Gary G GG Abraham Robert T RT Jiang Wei W
Molecular biology of the cell 20090708 17
The DNA replication machinery plays additional roles in S phase checkpoint control, although the identities of the replication proteins involved in checkpoint activation remain elusive. Here, we report that depletion of the prereplicative complex (pre-RC) protein Cdc6 causes human nontransformed diploid cells to arrest nonlethally in G1-G1/S and S phase, whereas multiple cancer cell lines undergo G1-G1/S arrest and cell death. These divergent phenotypes are dependent on the activation, or lack t ...[more]