Ontology highlight
ABSTRACT:
SUBMITTER: Blundell MP
PROVIDER: S-EPMC2736139 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Blundell Michael P MP Bouma Gerben G Metelo Joao J Worth Austen A Calle Yolanda Y Cowell Lucy A LA Westerberg Lisa S LS Moulding Dale A DA Mirando Samuel S Kinnon Christine C Cory Giles O GO Jones Gareth E GE Snapper Scott B SB Burns Siobhan O SO Thrasher Adrian J AJ
Proceedings of the National Academy of Sciences of the United States of America 20090901 37
The Wiskott-Aldrich syndrome protein (WASp) is a key cytoskeletal regulator in hematopoietic cells. Covalent modification of a conserved tyrosine by phosphorylation has emerged as an important potential determinant of activity, although the physiological significance remains uncertain. In a murine knockin model, mutation resulting in inability to phosphorylate Y293 (Y293F) mimicked many features of complete WASp-deficiency. Although a phosphomimicking mutant Y293E conferred enhanced actin-polyme ...[more]