USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics.

ABSTRACT: The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.

SUBMITTER: Lee EW 

PROVIDER: S-EPMC4909448 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other