Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice.

ABSTRACT:

Purpose

Individual differences in patterns of gene expression account for much of the diversity of ocular phenotypes and variation in disease risk. We examined the causes of expression differences, and in their linkage to sequence variants, functional differences, and ocular pathophysiology.

Methods

mRNAs from young adult eyes were hybridized to oligomer microarrays (Affymetrix M430v2). Data were embedded in GeneNetwork with millions of single nucleotide polymorphisms, custom array annotation, and information on complementary cellular, functional, and behavioral traits. The data include male and female samples from 28 common strains, 68 BXD recombinant inbred lines, as well as several mutants and knockouts.

Results

We provide a fully integrated resource to map, graph,

SUBMITTER: Geisert EE 

PROVIDER: S-EPMC2736153 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature