Ontology highlight
ABSTRACT:
SUBMITTER: Riemer J
PROVIDER: S-EPMC2736413 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Riemer Jan J Appenzeller-Herzog Christian C Johansson Linda L Bodenmiller Bernd B Hartmann-Petersen Rasmus R Ellgaard Lars L
Proceedings of the National Academy of Sciences of the United States of America 20090819 35
The quality control system of the endoplasmic reticulum (ER) discriminates between native and nonnative proteins. The latter are degraded by the ER-associated degradation (ERAD) pathway. Whereas many cytosolic and membrane components of this system are known, only few luminal players have been identified. In this study, we characterize ERFAD (ER flavoprotein associated with degradation), an ER luminal flavoprotein that functions in ERAD. Upon knockdown of ERFAD, the degradation of the ERAD model ...[more]