Ontology highlight
ABSTRACT:
SUBMITTER: Platten M
PROVIDER: S-EPMC2736463 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Platten Michael M Youssef Sawsan S Hur Eun Mi EM Ho Peggy P PP Han May H MH Lanz Tobias V TV Phillips Lori K LK Goldstein Matthew J MJ Bhat Roopa R Raine Cedric S CS Sobel Raymond A RA Steinman Lawrence L
Proceedings of the National Academy of Sciences of the United States of America 20090819 35
The renin-angiotensin-aldosterone system (RAAS) is a major regulator of blood pressure. The octapeptide angiotensin II (AII) is proteolytically processed from the decapeptide AI by angiotensin-converting enzyme (ACE), and then acts via angiotensin type 1 and type 2 receptors (AT1R and AT2R). Inhibitors of ACE and antagonists of the AT1R are used in the treatment of hypertension, myocardial infarction, and stroke. We now show that the RAAS also plays a major role in autoimmunity, exemplified by m ...[more]