Ontology highlight
ABSTRACT:
SUBMITTER: Orosco MM
PROVIDER: S-EPMC2736600 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Orosco Manuel M MM Pacholski Claudia C Sailor Michael J MJ
Nature nanotechnology 20090222 4
The activity of certain proteolytic enzymes is often an indicator of disease states such as cancer, stroke and neurodegeneracy, so there is a need for rapid assays that can characterize the kinetics and substrate specificity of enzymatic reactions. Nanostructured membranes can efficiently separate biomolecules, but coupling a sensitive detection method to such a membrane remains difficult. Here, we demonstrate a single mesoporous nanoreactor that can isolate and quantify in real time the reactio ...[more]