Microbial NAD metabolism: lessons from comparative genomics.
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ABSTRACT:
SUBMITTER: Gazzaniga F
PROVIDER: S-EPMC2738131 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Microbial NAD metabolism: lessons from comparative genomics.
Gazzaniga Francesca F Stebbins Rebecca R Chang Sheila Z SZ McPeek Mark A MA Brenner Charles C
Microbiology and molecular biology reviews : MMBR 20090901 3
NAD is a coenzyme for redox reactions and a substrate of NAD-consuming enzymes, including ADP-ribose transferases, Sir2-related protein lysine deacetylases, and bacterial DNA ligases. Microorganisms that synthesize NAD from as few as one to as many as five of the six identified biosynthetic precursors have been identified. De novo NAD synthesis from aspartate or tryptophan is neither universal nor strictly aerobic. Salvage NAD synthesis from nicotinamide, nicotinic acid, nicotinamide riboside, a ...[more]
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