Comparative genomics of transcriptional regulation of methionine metabolism in Proteobacteria.
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ABSTRACT:
SUBMITTER: Leyn SA
PROVIDER: S-EPMC4239095 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Comparative genomics of transcriptional regulation of methionine metabolism in Proteobacteria.
Leyn Semen A SA Suvorova Inna A IA Kholina Tatiana D TD Sherstneva Sofia S SS Novichkov Pavel S PS Gelfand Mikhail S MS Rodionov Dmitry A DA
PloS one 20141120 11
Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ∼ 200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the ...[more]
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