Ontology highlight
ABSTRACT:
SUBMITTER: Robinson CM
PROVIDER: S-EPMC2738150 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Robinson Christopher M CM Rajaiya Jaya J Walsh Michael P MP Seto Donald D Dyer David W DW Jones Morris S MS Chodosh James J
Journal of virology 20090624 17
Recombination in human adenoviruses (HAdV) may confer virulence upon an otherwise nonvirulent strain. The genome sequence of species D HAdV type 22 (HAdV-D22) revealed evidence for recombination with HAdV-D19 and HAdV-D37 within the capsid penton base gene. Bootscan analysis demonstrated that recombination sites within the penton base gene frame the coding sequences for the two external hypervariable loops in the protein. A similar pattern of recombination was evident within other HAdV-D types b ...[more]