Phage display selection of cyclic peptides that inhibit Andes virus infection.
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ABSTRACT:
SUBMITTER: Hall PR
PROVIDER: S-EPMC2738185 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
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Phage display selection of cyclic peptides that inhibit Andes virus infection.
Hall Pamela R PR Hjelle Brian B Njus Hadya H Ye Chunyan C Bondu-Hawkins Virginie V Brown David C DC Kilpatrick Kathleen A KA Larson Richard S RS
Journal of virology 20090610 17
Specific therapy is not available for hantavirus cardiopulmonary syndrome caused by Andes virus (ANDV). Peptides capable of blocking ANDV infection in vitro were identified using antibodies against ANDV surface glycoproteins Gn and Gc to competitively elute a cyclic nonapeptide-bearing phage display library from purified ANDV particles. Phage was examined for ANDV infection inhibition in vitro, and nonapeptides were synthesized based on the most-potent phage sequences. Three peptides showed leve ...[more]
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