Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC2738217 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Zhao Cong C Lou Zhiyong Z Guo Yu Y Ma Ming M Chen Yutao Y Liang Shuaiyi S Zhang Liang L Chen Shoudeng S Li Xuemei X Liu Yingfang Y Bartlam Mark M Rao Zihe Z
Journal of virology 20090708 18
Highly pathogenic influenza virus strains currently in circulation pose a significant risk of a global pandemic. Following the reported crystal structure of the endonuclease domain from the avian influenza virus polymerase PA subunit, here we report the results of a systematic X-ray crystallographic analysis of its complex with adenosine, uridine, and thymidine nucleoside monophosphates (NMPs). Electron density corresponding to the monophosphate moiety of each nucleotide was apparent in each NMP ...[more]