Role of oxysterol binding protein in hepatitis C virus infection.
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ABSTRACT:
SUBMITTER: Amako Y
PROVIDER: S-EPMC2738263 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Role of oxysterol binding protein in hepatitis C virus infection.
Amako Yutaka Y Sarkeshik Ali A Hotta Hak H Yates John J Siddiqui Aleem A
Journal of virology 20090701 18
Hepatitis C virus (HCV) RNA genome replicates within the ribonucleoprotein (RNP) complex in the modified membranous structures extended from endoplasmic reticulum. A proteomic analysis of HCV RNP complexes revealed the association of oxysterol binding protein (OSBP) as one of the components of these complexes. OSBP interacted with the N-terminal domain I of the HCV NS5A protein and colocalized to the Golgi compartment with NS5A. An OSBP-specific short hairpin RNA that partially downregulated OSB ...[more]
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