Recruitment of the transcriptional coactivator HCF-1 to viral immediate-early promoters during initiation of reactivation from latency of herpes simplex virus type 1.
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ABSTRACT:
SUBMITTER: Whitlow Z
PROVIDER: S-EPMC2738264 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Recruitment of the transcriptional coactivator HCF-1 to viral immediate-early promoters during initiation of reactivation from latency of herpes simplex virus type 1.
Whitlow Zackary Z Kristie Thomas M TM
Journal of virology 20090701 18
The transcriptional coactivator host cell factor 1 (HCF-1) is critical for the expression of immediate-early (IE) genes of the alphaherpesviruses herpes simplex virus type 1 (HSV-1) and varicella-zoster virus. HCF-1 may also be involved in the reactivation of these viruses from latency as it is sequestered in the cytoplasm of sensory neurons but is rapidly relocalized to the nucleus upon stimulation that results in reactivation. Here, chromatin immunoprecipitation assays demonstrate that HCF-1 i ...[more]
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Project description:This SuperSeries is composed of the SubSeries listed below.
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