Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC5490748 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wang Kening K Hoshino Yo Y Dowdell Kennichi K Bosch-Marce Marta M Myers Timothy G TG Sarmiento Mayra M Pesnicak Lesley L Krause Philip R PR Cohen Jeffrey I JI
The Journal of clinical investigation 20170605 7
Chronic viral infections are difficult to treat, and new approaches are needed, particularly those aimed at reducing reactivation by enhancing immune responses. Herpes simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation can occur despite suppressive antiviral therapy. Virus-specific T cells are important to control HSV, and proliferation of activated T cells requires increased metabolism of glutamine. Here, we found that supplementation with oral glu ...[more]