Ontology highlight
ABSTRACT:
SUBMITTER: Radakovits R
PROVIDER: S-EPMC2738639 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Radakovits Randor R Barros Claudia S CS Belvindrah Richard R Patton Bruce B Müller Ulrich U
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090601 24
Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also control the function of RGCs more directly. Here, we show that RGC numbers and cortical size are reduced in mice lacking beta1 integrins in RGCs. TUNEL stainings and time-lapse video recordings demonstrate that beta1-deficient RGCs processes detach from the meningeal basement mem ...[more]