The meninges enhance leukaemia survival in cerebral spinal fluid.
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ABSTRACT:
SUBMITTER: Basile P
PROVIDER: S-EPMC7192757 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
The meninges enhance leukaemia survival in cerebral spinal fluid.
Basile Patrick P Jonart Leslie M LM Ebadi Maryam M Johnson Kimberly K Kerfeld Morgan M Gordon Peter M PM
British journal of haematology 20200112 3
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mit ...[more]
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