Ontology highlight
ABSTRACT:
SUBMITTER: Chen YH
PROVIDER: S-EPMC2739582 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Chen Yu-hang YH He Lin-ling LL Buchanan Douglas R DR Zhang Yun Y Fitzmaurice Aileen A Yang Jian J
FEBS letters 20090508 12
The beta-subunit of voltage-gated Ca(2+) channels is essential for trafficking the channels to the plasma membrane and regulating their gating. It contains a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain, which interact intramolecularly. We investigated the structural underpinnings of this intramolecular coupling and found that in addition to a previously described SH3 domain beta strand, two structural elements are crucial for maintaining a strong and yet potentially modifiable ...[more]