Ontology highlight
ABSTRACT:
SUBMITTER: Summer R
PROVIDER: S-EPMC2739777 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Summer Ross R Fiack Christopher A CA Ikeda Yasumasa Y Sato Kaori K Dwyer Daniel D Ouchi Noriyuki N Fine Alan A Farber Harrison W HW Walsh Kenneth K
American journal of physiology. Lung cellular and molecular physiology 20090626 3
Adiponectin (APN) is an adipocyte-derived factor that exists at high concentrations in serum and has anti-inflammatory and systemic vascular-protective properties. In this study, we investigated the role of APN in pulmonary vascular homeostasis. We found that APN localizes to the luminal side of blood vessels in lung and acts in vitro to block TNF-alpha-induced E-selectin upregulation in pulmonary artery endothelial cells. Targeted deletion of the APN gene in mice leads to a vascular phenotype i ...[more]