Ontology highlight
ABSTRACT:
SUBMITTER: Raaijmakers HC
PROVIDER: S-EPMC2740583 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Raaijmakers Hans C A HC Versteegh Judith E JE Uitdehaag Joost C M JC
The Journal of biological chemistry 20090416 29
Here we describe the 1.95 A structure of the clinically used antiprogestin RU486 (mifepristone) in complex with the progesterone receptor (PR). The structure was obtained by taking a crystal of the PR ligand binding domain containing the agonist norethindrone and soaking it in a solution containing the antagonist RU486 for extended times. Clear ligand exchange could be observed in one copy of the PR ligand binding domain dimer in the crystal. RU486 binds while PR is in an agonistic conformation ...[more]