Ontology highlight
ABSTRACT:
SUBMITTER: Svensson S
PROVIDER: S-EPMC212723 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Svensson Stefan S Ostberg Tove T Jacobsson Micael M Norström Carina C Stefansson Karin K Hallén Dan D Johansson Isabel Climent IC Zachrisson Kristina K Ogg Derek D Jendeberg Lena L
The EMBO journal 20030901 18
The nuclear receptor heterodimers of liver X receptor (LXR) and retinoid X receptor (RXR) are key transcriptional regulators of genes involved in lipid homeostasis and inflammation. We report the crystal structure of the ligand-binding domains (LBDs) of LXRalpha and RXRbeta complexed to the synthetic LXR agonist T-0901317 and the RXR agonist methoprene acid (Protein Data Base entry 1UHL). Both LBDs are in agonist conformation with GRIP-1 peptides bound at the coactivator binding sites. T-0901317 ...[more]