Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC2740617 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Lee SaeHong S Wishart Matthew J MJ Williams John A JA
Biochemical and biophysical research communications 20090527 3
CRHSP-24 is a prominently regulated phosphoprotein in pancreatic acinar cells where it is the major substrate for the serine/threonine protein phosphatase, calcineurin, in response to secretagogues. We now identify the four regulated sites of CRHSP-24 phosphorylation as serines 30, 32, 41, and 52 and show that Ser(30) and Ser(32) are directly dephosphorylated by calcineurin. Coordinate phosphorylation/dephosphorylation of these four serines explains the multiple phosphorylated isoforms of CRHSP- ...[more]