Ontology highlight
ABSTRACT:
SUBMITTER: Rinehart J
PROVIDER: S-EPMC2811214 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Cell 20090801 3
Modulation of intracellular chloride concentration ([Cl(-)](i)) plays a fundamental role in cell volume regulation and neuronal response to GABA. Cl(-) exit via K-Cl cotransporters (KCCs) is a major determinant of [Cl(-)](I); however, mechanisms governing KCC activities are poorly understood. We identified two sites in KCC3 that are rapidly dephosphorylated in hypotonic conditions in cultured cells and human red blood cells in parallel with increased transport activity. Alanine substitutions at ...[more]