Ontology highlight
ABSTRACT:
SUBMITTER: Yung YC
PROVIDER: S-EPMC2741242 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Yung Yu Ching YC Chae Jeiwook J Buehler Markus J MJ Hunter Craig P CP Mooney David J DJ
Proceedings of the National Academy of Sciences of the United States of America 20090824 36
Mechanical signals regulate blood vessel development in vivo, and have been demonstrated to regulate signal transduction of endothelial cell (EC) and smooth muscle cell (SMC) phenotype in vitro. However, it is unclear how the complex process of angiogenesis, which involves multiple cell types and growth factors that act in a spatiotemporally regulated manner, is triggered by a mechanical input. Here, we describe a mechanism for modulating vascular cells during sequential stages of an in vitro mo ...[more]