Ontology highlight
ABSTRACT:
SUBMITTER: Back SH
PROVIDER: S-EPMC2742645 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Back Sung Hoon SH Scheuner Donalyn D Han Jaeseok J Song Benbo B Ribick Mark M Wang Junying J Gildersleeve Robert D RD Pennathur Subramaniam S Kaufman Randal J RJ
Cell metabolism 20090701 1
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2alpha). To elucidate the role of eIF2alpha phosphorylation, we engineered mice for conditional expression of homozygous Ser51Ala mutant eIF2alpha. The absence of eIF2alpha phosphorylation in beta cells caused a severe diabetic phenotype due to heightened and unregulated proinsulin translation; ...[more]