Ontology highlight
ABSTRACT:
SUBMITTER: Schenke-Layland K
PROVIDER: S-EPMC2742784 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Schenke-Layland Katja K Stock Ulrich A UA Nsair Ali A Xie Jiansong J Angelis Ekaterini E Fonseca Carissa G CG Larbig Robert R Mahajan Aman A Shivkumar Kalyanam K Fishbein Michael C MC MacLellan William R WR
European heart journal 20090627 18
<h4>Aims</h4>To increase the supply, many countries harvest allograft valves from explanted hearts of transplant recipients with ischaemic (ICM) or dilated cardiomyopathy (DCM). This study determines the structural integrity of valves from cardiomyopathic hearts.<h4>Methods and results</h4>Extracellular matrix (ECM) was examined in human valves obtained from normal, ICM, and DCM hearts. To confirm if ECM changes were directly related to the cardiomyopathy, we developed a porcine model of chronic ...[more]