Ontology highlight
ABSTRACT:
SUBMITTER: Gad HH
PROVIDER: S-EPMC2742852 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Gad Hans Henrik HH Dellgren Christoffer C Hamming Ole J OJ Vends Susanne S Paludan Søren R SR Hartmann Rune R
The Journal of biological chemistry 20090520 31
Interferon-lambda (IFN-lambda) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-lambdaR1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-lambda3 and characterized the interaction with its receptor complex through structure-based site-directed mutagenesis. The ability of IFN-lambda3 mutants to signal was determined by measuring the antiviral activity and induced STAT2 phosphorylation. In conclusion ...[more]