Lung cancer xenografting alters microRNA profile but not immunophenotype.
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ABSTRACT:
SUBMITTER: Bogner PN
PROVIDER: S-EPMC2742962 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
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Lung cancer xenografting alters microRNA profile but not immunophenotype.
Bogner Paul N PN Patnaik Santosh K SK Pitoniak Rose R Kannisto Eric E Repasky Elizabeth E Hylander Bonnie B Yendamuri Sai S Ramnath Nithya N
Biochemical and biophysical research communications 20090610 2
Lung tumor xenografts grown in immunocompromised mice provide a renewable source of tumor tissue for research and a means to study individualized response to chemotherapy. Critical to this utility is verification that the xenograft cells retain core phenotypic characteristics of the original tumor. We compared eight non-small cell lung carcinomas with their corresponding xenografts grown in mice with severe combined immunodeficiency by way of histology, immunohistochemistry, and microRNA express ...[more]
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