Body mass index and phenotype in subjects with mild-to-moderate persistent asthma.

ABSTRACT:

Background

Although obesity has been hypothesized to worsen asthma, data from studies of subjects with well-characterized asthma are lacking.

Objective

We sought to evaluate the relationship between body mass index (BMI), asthma impairment, and response to therapy.

Methods

BMI (in kilograms per meter squared) and asthma phenotypic and treatment response data were extracted from Asthma Clinical Research Network studies. The cross-sectional relationship between BMI and asthma impairment was analyzed, as was the longitudinal relationship between BMI and response to asthma controller therapies.

Results

One thousand two hundred sixty-five subjects with mild-to-moderate persistent asthma were evaluated. Analyses of lean versus overweight/obese asthmatic subjects demo

SUBMITTER: Sutherland ER 

PROVIDER: S-EPMC2743451 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature