Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC2743477 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Li Hedong H Han Yu R YR Bi Caixia C Davila Jonathan J Goff Loyal A LA Thompson Kevin K Swerdel Mavis M Camarillo Cynthia C Ricupero Christopher L CL Hart Ronald P RP Plummer Mark R MR Grumet Martin M
Developmental neurobiology 20081201 14
We have generated clones (L2.3 and RG3.6) of neural progenitors with radial glial properties from rat E14.5 cortex that differentiate into astrocytes, neurons, and oligodendrocytes. Here, we describe a different clone (L2.2) that gives rise exclusively to neurons, but not to glia. Neuronal differentiation of L2.2 cells was inhibited by bone morphogenic protein 2 (BMP2) and enhanced by Sonic Hedgehog (SHH) similar to cortical interneuron progenitors. Compared with L2.3, differentiating L2.2 cells ...[more]