Ontology highlight
ABSTRACT:
SUBMITTER: Pankratz MT
PROVIDER: S-EPMC2743478 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Pankratz Matthew T MT Li Xue-Jun XJ Lavaute Timothy M TM Lyons Elizabeth A EA Chen Xin X Zhang Su-Chun SC
Stem cells (Dayton, Ohio) 20070301 6
Understanding neuroectoderm formation and subsequent diversification to functional neural subtypes remains elusive. We show here that human embryonic stem cells (hESCs) differentiate to primitive neuroectoderm after 8-10 days. At this stage, cells uniformly exhibit columnar morphology and express neural markers, including anterior but not posterior homeodomain proteins. The anterior identity of these cells develops regardless of morphogens present during initial neuroectoderm specification. This ...[more]