Ontology highlight
ABSTRACT:
SUBMITTER: Smith AB
PROVIDER: S-EPMC2743491 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Smith Amos B AB Liu Zhuqing Z Hogan Anne-Marie L AM Dalisay Doralyn S DS Molinski Tadeusz F TF
Organic letters 20090801 16
A synthesis providing totally synthetic (+)-hemi-phorboxazole A (1), proceeding in two steps (85% yield) from known vinyl iodide precursor (+)-2, has been achieved in conjunction with the design, synthesis, and biological evaluation of two hemi-phorboxazole analogues [(+)-3 and (-)-4] featuring ring replacements inscribed within the macrolide. Although hemi-phorboxazole A (1) displayed no activity when tested against Candida albicans and two human cancer cell lines, analogue (-)-4 exhibited sign ...[more]