Ontology highlight
ABSTRACT:
SUBMITTER: Smith AB
PROVIDER: S-EPMC3146768 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Smith Amos B AB Hogan Anne-Marie L AM Liu Zhuqing Z Razler Thomas M TM Meis Regina M RM Morinaka Brandon I BI Molinski Tadeusz F TF
Tetrahedron 20110701 27-28
The design, synthesis and biological evaluation of a new phorboxazole analogue, comprising an acetal replacement for the C-ring tetrahdropyran of the natural product and carrying a potency-enhancing C(45-46) vinyl chloride side chain, is described. In addition, the synthesis of (+)-hemi-phorboxazole A and a series of related hemi-phorboxazole A analogues has been achieved. The new acetal ring replacement analogue displayed activity comparable to that of the parent natural product against HCT-116 ...[more]