Solution-phase parallel synthesis of a multi-substituted benzo[b]thiophene library.

ABSTRACT: Generation of a library using parallel syntheses of multi-substituted benzo[b]thiophenes is described. The requisite 3-iodobenzo[b]thiophenes are readily prepared in excellent yields from various alkynes bearing electron-rich aromatic rings by electrophilic cyclization using I(2) in CH(2)Cl(2). The heteroaromatic carbon-iodine bonds allow further diversification by palladium-catalyzed Suzuki-Miyaura, Sonogashira, Heck, and carboalkoxylation chemistry to give multi-substituted benzo[b]thiophene derivatives.

SUBMITTER: Cho CH 

PROVIDER: S-EPMC2743771 | biostudies-literature | 2009 Sep-Oct

REPOSITORIES: biostudies-literature