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Parallel solution-phase synthesis of an adenosine antibiotic analog library.

ABSTRACT: A library of eighty one adenosine antibiotic analogs was prepared under the Pilot Scale Library Program of the NIH Roadmap initiative from 5'-amino-5'-deoxy-2',3'-O-isopropylidene-adenosine 3. Diverse aldehyde, sulfonyl chloride and carboxylic acid reactant sets were condensed to 3, in solution-phase fashion, leading after acid-mediated hydrolysis to the targeted compounds in good yields and high purity. No marked antituberculosis or anticancer activity was noted on preliminary cellular testing, but these nucleoside analogs should be useful candidates for other types of biological activity.

SUBMITTER: Moukha-chafiq O

PROVIDER: S-EPMC3652606 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Parallel solution-phase synthesis of an adenosine antibiotic analog library.

Moukha-chafiq Omar O Reynolds Robert C RC

ACS combinatorial science 20130211 3

A library of eighty one adenosine antibiotic analogs was prepared under the Pilot Scale Library Program of the NIH Roadmap initiative from 5'-amino-5'-deoxy-2',3'-O-isopropylidene-adenosine 3. Diverse aldehyde, sulfonyl chloride and carboxylic acid reactant sets were condensed to 3, in solution-phase fashion, leading after acid-mediated hydrolysis to the targeted compounds in good yields and high purity. No marked antituberculosis or anticancer activity was noted on preliminary cellular testing, ...[more]

PMID: 23398694

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