Ontology highlight
ABSTRACT:
SUBMITTER: Muzikar KA
PROVIDER: S-EPMC2744631 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Muzikar Katy A KA Nickols Nicholas G NG Dervan Peter B PB
Proceedings of the National Academy of Sciences of the United States of America 20090915 39
The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms. The DNA-binding dependent mechanism occurs by direct binding of GR to glucocorticoid response elements (GREs) at regulatory regions of target genes. The DNA-binding independent mechanism involves binding of GR to transcription factors and coactivators that, in turn, contact DNA. A small mo ...[more]