Ontology highlight
ABSTRACT:
SUBMITTER: Sharma N
PROVIDER: S-EPMC6504996 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sharma Nikhil N Pollina Elizabeth A EA Nagy M Aurel MA Yap Ee-Lynn EL DiBiase Florence A FA Hrvatin Sinisa S Hu Linda L Lin Cindy C Greenberg Michael E ME
Neuron 20190304 2
Neuronal activity-dependent transcription is tuned to ensure precise gene induction during periods of heightened synaptic activity, allowing for appropriate responses of activated neurons within neural circuits. The consequences of aberrant induction of activity-dependent genes on neuronal physiology are not yet clear. Here, we demonstrate that, in the absence of synaptic excitation, the basic-helix-loop-helix (bHLH)-PAS family transcription factor ARNT2 recruits the NCoR2 co-repressor complex t ...[more]