Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC2744865 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Yang Jiahui J Pospisil Richard R Mage Rose G RG
Developmental and comparative immunology 20090103 5
Rabbits are widely used for vaccine development, and investigations of human infectious and autoimmune diseases such as Systemic Lupus Erythematosus (SLE). For these applications, we cloned, sequenced and expressed rabbit B-cell Activating Factor (BAFF), and localized BAFF in cells and tissues of the rabbit immune system. The rabbit homolog of the human BAFF binding site (miniBR3 peptide) within the BAFF-specific receptor BR3 was synthesized. This 26-residue core domain binds to recombinant rabb ...[more]