Ontology highlight
ABSTRACT:
SUBMITTER: McPhail KL
PROVIDER: S-EPMC2745555 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
McPhail Kerry L KL Correa Jhonny J Linington Roger G RG Gonzalez José J Ortega-Barría Eduardo E Capson Todd L TL Gerwick William H WH
Journal of natural products 20070419 6
As part of the Panama International Cooperative Biodiversity Groups (ICBG) project, two new (2, 4) and two known (1, 3) linear alkynoic lipopeptides have been isolated from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. Carmabin A (1), dragomabin (2), and dragonamide A (3) showed good antimalarial activity (IC50 4.3, 6.0, and 7.7 microM, respectively), whereas the nonaromatic analogue, dragonamide B (4), was inactive. The planar structures of all four compounds were determin ...[more]