Ontology highlight
ABSTRACT:
SUBMITTER: Farez MF
PROVIDER: S-EPMC2746562 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Farez Mauricio F MF Quintana Francisco J FJ Gandhi Roopali R Izquierdo Guillermo G Lucas Miguel M Weiner Howard L HL
Nature immunology 20090816 9
Multiple sclerosis is an inflammatory disease of the central nervous system that begins as a relapsing-remitting disease (RRMS) and is followed by a progressive phase (SPMS). The progressive phase causes the greatest disability and has no effective therapy, but the processes that drive SPMS are mostly unknown. Here we found higher serum concentrations of 15alpha-hydroxicholestene (15-HC) in patients with SPMS and in mice with secondary progressive experimental autoimmune encephalomyelitis (EAE) ...[more]