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Integrating costimulatory agonists to optimize immune-based cancer therapies.

ABSTRACT: While immunotherapy for cancer has become increasingly popular, clinical benefits for such approaches remain limited. This is likely due to tumor-associated immune suppression, particularly in the advanced-disease setting. Thus, a major goal of novel immunotherapeutic design has become the coordinate reversal of existing immune dysfunction and promotion of specific tumoricidal T-cell function. Costimulatory members of the TNF-receptor family are important regulators of T-cell-mediated immunity. Notably, agonist ligation of these receptors restores potent antitumor immunity in the tumor-bearing host. Current Phase I/II evaluation of TNF-receptor agonists as single-modality therapies will illuminate their safety, mechanism(s) of action, and best use in prospective combinational immunotherapy approaches capable of yielding superior benefits to cancer patients.

SUBMITTER: Pardee AD

PROVIDER: S-EPMC2746690 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Integrating costimulatory agonists to optimize immune-based cancer therapies.

Pardee Angela D AD Wesa Amy K AK Storkus Walter J WJ

Immunotherapy 20090301 2

While immunotherapy for cancer has become increasingly popular, clinical benefits for such approaches remain limited. This is likely due to tumor-associated immune suppression, particularly in the advanced-disease setting. Thus, a major goal of novel immunotherapeutic design has become the coordinate reversal of existing immune dysfunction and promotion of specific tumoricidal T-cell function. Costimulatory members of the TNF-receptor family are important regulators of T-cell-mediated immunity. ...[more]

PMID: 20046961

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