Ontology highlight
ABSTRACT:
SUBMITTER: Tsai SJ
PROVIDER: S-EPMC2747803 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Tsai Sophia J SJ Sen Udayaditya U Zhao Lei L Greenleaf William B WB Dasgupta Jhimli J Fiorillo Edoardo E Orrú Valeria V Bottini Nunzio N Chen Xiaojiang S XS
Biochemistry 20090601 22
The lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, recently emerged as an important risk factor and drug target for human autoimmunity. Here we solved the structure of the catalytic domain of LYP, which revealed noticeable differences with previously published structures. The active center with a semi-closed conformation binds a phosphate ion, which may represent an intermediate conformation after dephosphorylation of the substrate but before release of the phosphate product. T ...[more]