Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3113683 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Liu Yingge Y Stanford Stephanie M SM Jog Sonali P SP Fiorillo Edoardo E Orrú Valeria V Comai Lucio L Bottini Nunzio N
Biochemistry 20090801 31
The lymphoid tyrosine phosphatase LYP, encoded by the PTPN22 gene, recently emerged as a major player and candidate drug target for human autoimmunity. The enzyme includes a classical N-terminal protein tyrosine phosphatase catalytic domain and a C-terminal PEST-enriched domain, separated by an approximately 300-amino acid interdomain. Little is known about the regulation of LYP. Herein, by analysis of serial truncation mutants of LYP, we show that the phosphatase activity is strongly inhibited ...[more]