Ontology highlight
ABSTRACT:
SUBMITTER: Tree JJ
PROVIDER: S-EPMC2747932 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Tree Jai J JJ Wang Dai D McInally Carol C Mahajan Arvind A Layton Abigail A Houghton Irene I Elofsson Mikael M Stevens Mark P MP Gally David L DL Roe Andrew J AJ
Infection and immunity 20090727 10
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of Escherichia coli O157:H7 in liquid culture and when this bacterium is attached to bovine epithelial cells. Inhibition of T3SS expression resulted in a reduction in the capacity of the bacteria to form attaching and effacing lesions. Our results show that there is marked ...[more]