Ontology highlight
ABSTRACT:
SUBMITTER: Deng Y
PROVIDER: S-EPMC2748117 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Deng Yijun Y Wang Yiqiang Y Cherian Christina C Hou Zhanjun Z Buck Steven A SA Matherly Larry H LH Gangjee Aleem A
Journal of medicinal chemistry 20080805 16
6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge between the heterocycle and the benzoyl-L-glutamate (compounds 2-5, respectively) were synthesized starting from methyl 4-formylbenzoate and a Wittig reaction with the appropriate triphenylphosphonium bromide, followed by reduction and conversion to the alpha-bromomethylketones. Cyclocondensation of 2,4-diamino-4-oxopyrimidine with the alpha-bromoketones, coupling with diethyl-L-glutamate, and saponif ...[more]