Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3209708 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Wang Lei L Desmoulin Sita Kugel SK Cherian Christina C Polin Lisa L White Kathryn K Kushner Juiwanna J Fulterer Andreas A Chang Min-Hwang MH Mitchell-Ryan Shermaine S Stout Mark M Romero Michael F MF Hou Zhanjun Z Matherly Larry H LH Gangjee Aleem A
Journal of medicinal chemistry 20110922 20
2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine antifolates with a thienoyl side chain (compounds 1-3, respectively) were synthesized for comparison with compound 4, the previous lead compound of this series. Conversion of hydroxyl acetylen-thiophene carboxylic esters to thiophenyl-α-bromomethylketones and condensation with 2,4-diamino-6-hydroxypyrimidine afforded the 6-substituted pyrrolo[2,3-d]pyrimidine compounds of type 18 and 19. Coupling with l-glutamate diethyl ester, followed by sap ...[more]