Ontology highlight
ABSTRACT:
SUBMITTER: Xue Y
PROVIDER: S-EPMC2748900 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Xue Yali Y Wang Qiuju Q Long Quan Q Ng Bee Ling BL Swerdlow Harold H Burton John J Skuce Carl C Taylor Ruth R Abdellah Zahra Z Zhao Yali Y MacArthur Daniel G DG Quail Michael A MA Carter Nigel P NP Yang Huanming H Tyler-Smith Chris C
Current biology : CB 20090827 17
Understanding the key process of human mutation is important for many aspects of medical genetics and human evolution. In the past, estimates of mutation rates have generally been inferred from phenotypic observations or comparisons of homologous sequences among closely related species. Here, we apply new sequencing technology to measure directly one mutation rate, that of base substitutions on the human Y chromosome. The Y chromosomes of two individuals separated by 13 generations were flow sor ...[more]