Ontology highlight
ABSTRACT:
SUBMITTER: Chen YL
PROVIDER: S-EPMC2749122 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Chen Yue-Lei YL Liu Bin B Zhou Zhen-Ning ZN Hu Rui-Ying RY Fei Cong C Xie Zhi-Hui ZH Ding Xiaoyan X
The Journal of biological chemistry 20090626 35
Members of the bone morphogenetic protein (BMP) and T-box gene families play several critical roles in the early embryonic development and tissue homeostasis. Although BMP proteins are the upstream regulators of T-box genes, few studies have investigated the molecular mechanisms between these two protein families. Here, we report that Tbx6 interacts directly with Smad6, an inhibitory Smad that antagonizes the BMP signal. This interaction is mediated through the Mad homology 2 (MH2) domain of Sma ...[more]